Imipramine in Schizophrenia with Depressive Symptomatology1
نویسندگان
چکیده
Depressive mood is a common accompaniment of schizophrenia. The present study was taken up with the aim to study the effect of imipramine on depressivse symptoms of schizophrenia. Eighteen patients of schizophrenia with depressive symptoms were studied under a double blind controlled design with a chlorpromazine-imipramine and a chlorpromazine-placebo group. Both the groups showed significant improvement (p< .001) after the 6 week trial and the addition of imipramine to chlorpromazine therapy did not have any advantageous or deleterious effect.
منابع مشابه
Treatment of postpsychotic depression with sertraline in patients with schizophrenia.
Some authors treated a two groups of patients with postpsychotic depression in a groups of patients with schizophrenia. Sertraline proved better than imipramine in view of earlier onset of action and lower incidence, intensity and duration of adverse effects and lower risk of schizophrenie symtom recurrence (Ref 4).
متن کاملRandomized Controlled Trials of Add-On Antidepressants in Schizophrenia
BACKGROUND Despite adequate treatment with antipsychotics, a substantial number of patients with schizophrenia demonstrate only suboptimal clinical outcome. To overcome this challenge, various psychopharmacological combination strategies have been used, including antidepressants added to antipsychotics. METHODS To analyze the efficacy of add-on antidepressants for the treatment of negative, p...
متن کاملA Comparison of Selective Attention Processing in Major Depressive Disorder and Schizophrenia
Objective: Cognitive deficits play an important role in differential diagnostics, prognosis and rehabilitation of people with psychological disorders. Attention problems have profound impact on the therapeutic response, risk of relapse, function and quality of life in people with major depressive disorder and schizophrenia. This study compared selective attention of people with schizophrenia, M...
متن کاملThe effects of imipramine on P50 suppression, prepulse inhibition and habituation of the startle response in humans.
Schizophrenic patients exhibit impairments in filtering of sensory information, as can be assessed by use of prepulse inhibition (PPI) of the acoustic startle response and P50 suppression paradigms. In the treatment of negative symptoms or depressive syndromes during the course of schizophrenia antidepressants are often combined with antipsychotic medication. However, antidepressants increase m...
متن کاملEfficacy of Risperidone Augmentation with Ondansetron in the Treatment of Negative and Depressive Symptoms in Schizophrenia: A Randomized Clinical Trial
Background: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia.Methods: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 32 شماره
صفحات -
تاریخ انتشار 1990